Clinical Evidence

Uncontrolled Parkinson’s Disease (PD) is widespread.  It is estimated that up to 80% of Parkinson’s Disease patients have uncontrolled symptomology and these, typically treatable, symptoms can cause poor quality of life & significant patient morbidity.^1-3

A study published in Nature (njp) Parkinson’s Disease, 78% of patients were found to have had uncontrolled symptoms via the PKG.  Subsequent treatment of those patients towards control guided by PKG target ranges resulted in significant improvements in patient outcomes including quality of life and cognition (significant improvement in PDQ-39 of 8.5 [p = 0.03]; Total UPDRS improved by 8 [p <0.0009]; NMS Quest improved by 1 [p= 0.02]; and MOCA scores improved by 2 [p = 0.02]).²

A recently published study demonstrated that the PKG changed medications in PD patients 75% of the time. MDS-UPDRS III score improved 4.8 points from 28.9 to 24.1 points (p = 0.028); both statistically significant and clinically meaningful difference. MDS-UPDRS IV score improved from 4.1 to 3.0 points (p = 0.07).  The PKG influenced treatment plans demonstrated by improvement in Global Impression of Improvement Positive changes in both the clinician (17/28; 61%) and patient-reported (13/24; 54%). Clinical management plans enhanced by PKG led to different recommendations in 29.4% of cases compared with standard of care due to higher rates of bradykinesia, dyskinesia, tremor, and fluctuations identified by PKG. ⁴

A study completed in the UK demonstrated that the PKG changed the medical decision of the physician 47% (80 of 171 decisions) of the time.  34% (27 of 80 changed decisions) were decisions related to referring patients for advanced therapies (e.g. DBS, infusional drugs); 29.2% of 171 (49 patients) were considered for advanced therapies and in 26% (13 of 49) advanced therapy was no longer determined to be considered the next step.⁶

Additional impact of the PKG on Patient Care reported by clinicians:

Improved education about illness (15%), symptoms (29%), ability to assess patient PD symptoms (33%); total of 77% across 65 visits⁵

74% reported PKG to be somewhat or very valuable in helping take medications on time (by function of the medication reminders), explain symptoms and provide additional information to manage care for PD

61% found valuable in providing data to the physician on daily movement during daily activities

57% stated the PKG was valuable in overall management of symptoms

52% of patients found the PKG valuable in taking medications on time⁵